Investing via Vickers and POEMS for VUSA or VUSD - which will be better? Or any other recommendations?

Both are fine. maybe there are subtle differences on different stock exchanges (Germany versus London) as to stamp duties and of course spreads, but with ultra-longterm buy & hold neglegible.

But in general I feel VUSA/VUSD is a super-excellent first choice when investing. Even distributed around 2% dividends annually...