What’s the difference between investing in AXS on the crypto exchange vs to owning an axie on the game itself?

The AXS token is part of the game's tokenomics, and is used by holders to participate in governance, staking, or paying for in-game stuff. On the other hand, Axies are the NFT pets you see in-game, and they can be traded on NFT marketplaces.

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If you are looking to invest in-play-to-earn tokens, there are quite a number of them around especially after the success of Axie Infinity.

Investing in AXS coins is like buying a share from a listed company. It makes you a shareholder and you should only do it when you trust the management team and their future potential